Fig. 1
From: Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective
Developmental process of CD8+ T cell lineages. High T-bet expression, which is induced by high levels of inflammatory cytokines (i.e., IL-12), induces CD127lo SLEC, while low T-bet expression promotes the induction of CD127hi MPEC, which are capable of generating long-lived memory CD8+ T cells. KLRG1+ T cells receiving intermediate amounts of inflammatory signals downregulates KLRG1 in a Bach2-dependent manner and differentiated into all memory T cell linages. SLEC short-lived effector cells, MPEC memory precursor effector cells, KLRG1 killer cell lectin-like receptor G1, TN naïve T cells, TEF effector T cells, TRM tissue-resident memory T cells, TEM effector memory T cells, TCM central memory T cells