Fig. 2
From: Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective
Transcriptional network of TRM. Hobit and Blimp1 govern the transcriptional program of TRM by suppressing the expression of genes related to tissue egress. Coordinated downregulation of Eomes and T-bet is crucial for TGF-β signaling, which is required for efficient TRM formation. TGF-β, in turn, downregulates Eomes and T-bet expression. TGF-β induces the expression of CD103 and controls various aspects of TRM development in different tissues. CD69 limits egress from lymphoid organs and peripheral tissues by antagonizing S1PR1